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The current invention provides a new approach for Circularly Polarized Luminescence (CPL) and Vibrational Optical Activity (VOA), Raman Optical Activity (ROA) spectroscopy that simplify the apparatus design, reduces the artefacts and enables simultaneous detection of the left and right circular component of the light out coming from the sample. The above-mentioned grating generates only the fields diffracted to the first order, whose amplitudes are proportional to the right and left circular components of the light beam impinging onto the grating. The method of the present invention demonstrates that, by using these characteristics of the grating, the chiroptical properties of a medium can be easily determined by sending the light beam coming from the sample to be analysed, onto the grating, and measuring the intensity of the beams diffracted by the grating.

-The method is based on the use of a single element, other optical elements (polarizer, mirrors, wave plates, etc.) are not required, implying a reduction of the light losses and artefacts;
-The method enables simultaneous measurements of the left and right circular components of the light at the exit of the sample.
-The dispersion properties of the grating allow measurements in real time to be taken, in fact the signal at every wavelength diffracted at different angles can be detected in parallel by a photodiodes array or a CCD;
-Monochromator and phase sensitive detector are not necessary;
-Moving or time-modulated elements are not present;
-Decrease of the production costs because it does not require optical and/or electro-optical elements as the standard systems do;
-Performances enhancement, real time measurements due to the absence of moving elements, extremely simplified calibration procedures of the system;
-Real time measurement implies the possibility to investigate dynamic processes;
-The device can be integrated into multifunctional apparatus and is able for “in situ” measurements.

It is a powerful spectroscopic method to probe of the structure and behaviour of biomolecules in aqueous solutions, including peptides, proteins, carbohydrates, nucleic acids and viruses.

Proof of Concept.

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