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You selected inventions in category Life Sciences

  • Process of preparation of diabetic remedyProcess of preparation of diabetic remedy
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      Present technology is related to a process for extracting an herbal product for prevention of diabetic nephropathy, radiation hazards and age related chronic diseases. The objective of present technology is to develop a herbal product, which could be helpful in preventing diabetic nephropathy and other pathologies, related to over activation of PKC pathway such as DNA break due to radiation and chemotherapy, apoptosis of beta cells, early aging, over expression of inflammatory genes.

      What is Novelty
      • Novel plant extract is used for treatment of diabetics and its mechanism of action was also not known.

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    • Production of melanin from fungusProduction of melanin from fungus
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        This technology is related to process of production of melanin. According to this technology melanin can be easily produced by growing fungus in culture medium.The fungus used in technology is natural and wild type organism. The melanin is secreted externally into the culture medium and is harvested from there. It is a natural melanin and not synthetic.
        What is Novelty
        • Earlier melanin production technologies uses genetically modified organism whereas this technology uses natural organism.
        • Melanin produced from earlier technologies is synthetic and expensive while melanin obtained from present technology is natural and inexpensive.

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      • A novel method of Methanone PreparationA novel method of Methanone Preparation
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          The present technology provides a process for the preparation of methanone, the said process comprising steps of:
          (a) condensing a halo-quinoline with an α.-picolyl derivative in the presence of an organic solvent, a base and a phase transfer catalyst at -10 degree to +90 degree C.;
          (b) adding an oxidizing agent to the reaction mixture of step (a) containing the acetonitrile derivative at -10 degree to +90 degree C.;
          (c) cooling the reaction mixture of step (b) and neutralizing with any suitable acid followed by extraction with an organic solvent.
          (d) removing the organic solvent of step (c) and crystallizing the Methanone
          The entire process described above is carried out in the same vessel, without the need to isolate the acetonitrile intermediate. The process is thus an improvement over all existing and known methods.

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        • A novel process for -amino acid amides synthesisA novel process for -amino acid amides synthesis
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            The present technology provides with an amidation reaction of unprotected a-amino acids in water under neutral conditions with various aliphatic, aromatic and heteroaromatic amines in the presence of coupling reagent l,l'-carbonyldiimidazole (CDI) at ambient temperature to obtain the corresponding a-amino acid amides. This method offers a novel way for amidation of unprotected α-amino acids in one pot reaction. The said amidation reaction can be performed on free as well as hydrochloride salts of amino acids and the side-chain functionality was found to be relatively unaffected by the reagent and reaction conditions. Moreover, the reaction was found to be stereo-conservative in nature, and no apparent racemization of the final products was observed.

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          • Process of Preparation of TriprolidineProcess of Preparation of Triprolidine
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              This technology is related to Non-infringing process of preparing of Triprolidine . This technology produce triprolidine in less number of synthetic steps compared to existing technologies. Hence this technology save the reagents and eventually leads to time and cost effective.

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            • Process of Preparation of ErlotinibProcess of Preparation of Erlotinib
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                This technology is related to process of preparing of Erlotinib

                What is Novelty?
                The earlier technologies for preparing [6,7-bis-(2methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride (Erlotinib) having low yield about 50% -75% whereas present technology gives high yield, in addition has significant advantage in terms of time and cost. This technology can produce Erlotinib in less synthetic steps.

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              • Process of Preparation of anticancer drugProcess of Preparation of anticancer drug
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                  This technology is related to process of preparing of [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride (Erlotinib)
                  What is Novelty?
                  The earlier technologies for preparing [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride (Erlotinib) having low yield about 50% -75% whereas present technology gives high yield, in addition has significant advantage in terms of time and cost. This technology can produce Erlotinib in less synthetic steps.

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                • Process of Preparation of anticancer APIProcess of Preparation of anticancer API
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                    This technology is related to process of preparing 4-(3-chloro -4-fluorophenylamino) -7-methoxy -6- [3-(4-morpholinyl) propoxy] quinazoline.

                    What is Novelty?
                    The earlier technologies for preparing Gefitinib had low yield about 50% -75% whereas present technology gives high yield, in addition has significant advantage in terms of time and cost. This technology can produce Gefitinib in less synthetic steps.

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