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You selected inventions in category Biology

  • Interfacially active enzymes for EsterificationInterfacially active enzymes for Esterification
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      The present technology suggests a process for the preparation of esters using an interfacially active enzyme (lipase). Esterification is an important reaction in oleochemical industry with products of confectionary, cosmetic and dietary importance. In recent times lipases are utilized in oleochemical industry for their ability to function in organic solvent.

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    • Stable gene variants of LipasesStable gene variants of Lipases
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        The present technology encompasses methods for generating variation in gene sequences (of E. coli Lipase), provides protocols for screening the enzymes with higher thermostability and also protocols for sequencing and expression.

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      • Insulin measuring deviceInsulin measuring device
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          The present technology suggests a device for estimating the level of insulin in the body. The said device makes use of a biocomponent which is immobilized within the carbon paste in case of CPE (carbon paste electrode) and covalently immobilized by glutaraldehyde in case of SPE (screen printed electrode). The response of the immobilized biocomponent is seen amperometrically. The developed biosensor has been applied to monitor insulin in the normal individual and diabetics patients.

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        • HIV-1 Subtype C Therapeutic VaccineHIV-1 Subtype C Therapeutic Vaccine
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            This technology relates to the augmentation of HIV specific immune response by co-immunization with HIV-1 vaccinogens and immunomodulators like Immunostimulatory sequences which help the patient in combating and controlling the virus replication in them.

            The combination of vaccinogens and Immunomodulators are selected from CpG motifs and recombinant plasmids vaccine construct; Interleukin-2 and recombinant plasmids; CpG motifs, interleukin-2 and recombinant plasmids; CpG motifs and recombinant viral vector vaccine constructs; Interleukin-2 and recombinant viral vector vaccine constructs; CpG motifs, interleukin-2 and recombinant viral vector vaccine constructs.

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          • Rapid Fracture healing agentsRapid Fracture healing agents
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              The technology suggests a 5 steps reaction process for the preparation of substituted benzfurochromenes and related compounds for the prevention and treatment of bone related disorders. The said compounds activate osteoblastic ER (Estrogen receptor) which in turn stimulate BMP-2 (Bone morphogenetic protein) secretion. The secretion thus produced helps in bone forming and strengthening activity. The healing effect of this technology has been tested in rabbits.

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            • A novel dye for staining proteins on a gelA novel dye for staining proteins on a gel
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                The technology provides a dye composition prepared from Lawsonia inermis for staining proteins on a gel. The dye composition of the present technology comprises petrol based of henna leaves, ammonia, lemon juice and ethanol. The technology also provides a method for preparing the dye composition and a method for conducting sodium-dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) assay using the said dye which is advantageous over the conventionally followed methods.

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              • Animal model system to study pathogenesisAnimal model system to study pathogenesis
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                  The technology suggests methods for studying pathogenesis of mammalian viruses [Vesicular Stomatitis Virus (VSV)] utilizing a nonhuman Caenorhabditis elegans (C. elegans) animal model system.

                  “Infection System” - C. elegans infected by animal virus identify:
                  1) Host determinants for susceptibility to viral infections,
                  2) Path ways and key mediators of these pathways, and
                  3) New leads for development of antivirals or for evaluating the efficacy of antivirals on individual host genetic backgrounds.

                  The technology demonstrates that the disease can be generated in the nematode, C. elegans upon exposure to VSV, a virus that infects mammalian cells. This discovery demonstrates that a simple animal model system can be used to study the disease pathogenesis of mammalian viruses. The technology further demonstrates that VSV can cause disease in C. elegans, an invertebrate that was not previously known to be infected by VSV or other vertebrate animal viruses.

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                • Biodegradable microparticles for drug deliveryBiodegradable microparticles for drug delivery
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                    The technology is based on a suspension-encapsulation technique that is readily controllable using a unique non-organic approach and is thus a very attractive drug delivery method for several products currently in the market. This process uses inorganic materials (e.g., hydroxyapatite) that can be easily removed after encapsulation has been completed. The solidified micro-particles produced by this technology are devoid of contaminating micro-particles and can be recovered by centrifuge and filtration much more reproducibility.

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