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You selected inventions in category Biotech

  • “DISPENSE ALL” - A new way to package and dispense products“DISPENSE ALL” - A new way to package and...
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      This invention relates to the manufacturing of a packaging/bottle to dispense a product in a controlled and measured way, as desired/needed by the user. This packaging/bottle design will be utilized by all industries using paste, ointment, semi-liquid and liquid products. All these type of products will be packaged in a dispenser / bottle type package to be known as 'DISPENSE ALL'

      For more information contact aquabelle@hotmail.com

      https://youtu.be/5f92ciZ7RTQ

      https://youtu.be/oYwaPJA6U-A

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    • Patents related with GIPsFILIP1L filamin A-interacting protein 1-like proteinsPatents related with GIPsFILIP1L filamin...
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        In Fibrostatin SL we have some issued patents related with GIPs/FILIP1L (filamin A-interacting protein 1-like) proteins that we would like to sell or license. The patents are:

        US Patent 7147855, US Patent 7601349, Australia Patent 2002365637, Japan Patent 4201712.

        The invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical compositions thereof. The present invention also provides isolated GIP90/130 nucleic acid sequences, expression vectors comprising the nucleic acid sequences, and host cells transfected with the expression vectors.

        FILIP1L proteins have been recognized as putative targets in cancer (Kwon M, Libutti SK.. 2014. Expert Opin Ther Targets. 18:1435-47.). GIPs are 90-kDa and 130-kDa FILIP1L isoforms that bind to Goodpasture antigen binding protein (GPBP) also known as Ceramide transfer protein or CERT. FILIP1L-130 kDa and GPBP are involved in myofibril formation (Revert-Ros et al. 2011. J Biol Chem. 286:35030-43.)

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      • DIAGNOSTIC TEST OF STREPTOCOCCUS AGALACTIAE INFECTIONS  IN PREGNANT WOMENDIAGNOSTIC TEST OF STREPTOCOCCUS AGALACTIAE...
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          The offer is a new diagnostic test which may confirm the Streptococcus agalactiae infections in pregnant women. The proposed test uses a specific reaction of immunoreactive proteins derived from clinical isolates of S. agalactiae with the antibodies present in the serum of patients, and provides an alternative to commonly used solutions in this field.

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        • Intelligent system for detecting tooth decay using piezo vibration and 100 accuracyIntelligent system for detecting tooth decay...
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            Always Special attention has been paid to the accurate diagnosis of dental caries in dentistry.
            To detect dental caries At the occlusal levels via The perfect mirror And at interdental levels The use of radiographs of Bytewing .
            addition to the cost of Preparing radiographs , It expands the patient to x-rays, which itself has multiple complications.
            Different radiographic systems are one of the main diagnostic tools in dentistry.
            As a result of an increase in the number of illnesses resulting from laser imaging that is the result of this radiation , And the increase in radiation damage to humans.
            The best way to detect with 100% accuracy And without zero percentages, To improve the quality of decay detection and Renounce all the problems listed , Decided to design got this device.

            The complications and problems of radiographic systems:

            **Diseases of the skin and cancer caused by x-rays for dentists and patients
            **Physical complications for pregnant women in embryos
            **High cost in the preparation and maintenance of radiographic equipment
            **Lack of accurate diagnosis of decay (detection of up to 60%) Or the separation of amalgam from the tooth (detecting up to 25%) in the restorative tooth By radiography devices
            **Detection of decay (detection 0%) or separation of amalgam substance from the tooth in restorative tooth by oral sensors

            ** Specific objectives of the project

            1. Record the waves from healthy teeth
            2. Record the waves from the teeth with 0.5 mm cavities
            3. Record waves from teeth with 1 mm cavities
            4. Record waves from 1.5 mm cavities
            5. Record waves from teeth with 2 mm cavities
            6. Compare the two primitive groups together
            7. Record radiographs of sample teeth
            8. Review the synchronization of radiographic images with the designed model

            ** Applied Schemes

            • Possibility of examining tooth decay in pregnant women and the elderly
            • Facilitating the examination of dental caries and studying the separation of amalgam from the tooth in restored teeth ,dont need to go to radiographic centers And exposure to laser radiation (Notably, the most advanced X-ray devices are not able to do it)
            • High accuracy of detection than radiography devices up to 100% accuracy of detection
            • Cheaper prices, so all dentists will be able to buy this device
            • Because of its low cost of service, it does not cost much, and it's a welfare for patients
            • Avoiding time to go to the radiography clinic and returning to the dentist's office.

            Teeth are randomly divided into 5 groups of 20 teeth. In groups 1-4, cavities at 0.5, 1, 1.5 and 2 depths in the teeth will be created as a decay model. In the fifth group, no cavity will be created. By contacting the ultrasonic probe with the teeth, the waves received by the detector will be recorded.




            The next steps are as follows:
            1- 3D modeling of the device in Solidworkes 2016 Software
            2. Load dynamic forces and dynamic analysis with MC Adams software
            3. The loading forces of motion and vibration analysis software ANSYS 17.1
            4. Vibration testing of teeth with ME Scope software for comparison with modeling analysis
            Next step The teeth are parallel radiographs and the result will be compared with the model. Statistical analysis of data By one-agent variance analysis and The appropriate follow-up is used to compare two-dimensional groups in groups.

            At this point, our data will be ready for the device library And the device becomes the program.

            The cost of the Intelligent system for detecting tooth decay using piezo vibration and 100% accuracy:

            **Making the original model Body with a beautiful look:2500$
            **Modal and harmonic vibration testing on 200 human tooth samples ( We will receive from the bank of dentistry of medicin university):19000$
            **Build a humanoid robot to move and sit on a dental unit To view system performance :4000$

            Total:65000$

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          • Intelligent systems alternative to anesthetic treatment of dental and medical procedures Without the injection of any Anesthetic and Only using a special fixture For surgery and Dental surgeryIntelligent systems alternative to anesthetic...
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              ** Specific objectives of the project:

              • Non-use of anesthetics in dentistry and in the next step for surgery of human organs
              • Measuring the actual rate of pain and fixing it and applying anti-acne in the form of nano-electric shocks

              ** Applied Schemes:

              • Possibility of dental surgery without any pain or stress that is present in all patients referred to the doctor)
              Facilitate dental operations Because of no pain (In most cases, despite the numbness in the intensity is palpable)
              • Not having any side effects for humans in the short or long term
              • Persuading people To provide health for oral and dental health and Increasing social health
              • No pain will be touched by the patient And will not touch any sensation of electrical shock

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            • Nanoparticles Of Cerium Oxide Targeted To An Amyloid-Beta Antigen Of Alzheimers Disease And Associated MethodsNanoparticles Of Cerium Oxide Targeted To An...
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                Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.

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              • A new drug for the prevention and treatment of human influenza A virus IAV human metapneumovirus hMPV and human rhinoviruses HRVA new drug for the prevention and treatment of...
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                  Potential drug: a modified polyallylamine derivative

                  Application: prevention and treatment of human influenza A virus (IAV), human metapneumovirus (hMPV) and human rhinoviruses (HRV)

                  Influenza is an acute infectious disease caused by viruses belonging to the Orthomyxoviridae family, and classified into three types: A, B and C. This classification is based on antigenic differences between the major virion proteins, e.g. M protein and nucleoprotein NP. These types differ in terms of epidemiological properties.

                  Influenza A virus (IAV) causes acute and chronic respiratory infections. It is a major respiratory pathogen of humans and animals. A period of frequent influenza infections occurs each winter (seasonal flu, the highest incidence occurring
                  in January/February). Only type A influenza virus causes epidemics and pandemics because of antigenic shift that is multiple changes in the various genome segments resulting from reassortment of different strains of the virus.

                  According to the World Health Organization (WHO) infections with influenza
                  and influenza-like viruses occur globally with an annual attack rate estimated at 5%-10% in adults and 20%-30% in children. Worldwide, these annual epidemics are estimated to result in about 3 to 5 million cases of severe illness, and about 250 000 to 500 000 deaths. The most severe infections develop in children under two years of age, in the elderly aged 65 or older and in those with compromised immunity. WHO recommends vaccination against the influenza virus as the most effective way to prevent infections. On the other hand, because of a large variability of the virus, the difficulty in obtaining sufficient number of vaccines before the epidemic wave, and not always satisfactory efficacy of the vaccine and anti – influenza drugs, the disease still represents an important medical and epidemiological problem. Therefore, new effective drugs for the anti-influenza treatment are needed.

                  The new invention of the Jagiellonian University, which is the subject
                  of the proposed offer, discloses a new drug for the treatment of human A virus (IAV) infection.

                  Human metapneumovirus (hMPV) was identified in 2001, however, it was proved that infections with this pathogen have occurred in the human population for
                  at least 50 years now. It is the only known Pneumovirus which infects humans and causes both upper and lower respiratory tract infections. Respiratory infections caused by hMPV have been reported in patients of every age and gender,
                  but children under 5 years are most likely to be susceptible to infections caused
                  by hMPV. The clinical manifestations of hMPV disease are flu-like symptoms such
                  as runny nose, cough, sore throat and high fever. The virus is widespread, and is found on all continents. Late winter and early spring is the epidemic peak of hMPV infections. More serious symptoms, including severe lower respiratory tract infections, are found mainly in young children and infants under 5 years
                  of age, elderly individuals above 60 years of age, and immunocompromised patients, whereas immunocompetent adults present mostly flu-like illnesses or cold symptoms.
                  So far, no other drug has been approved for inhibition and prevention
                  of infections caused by hMPV. By 2012, the only drugs with broad spectrum
                  of activity (such as ribavirin and immunoglobulins) have been used to treat very acute, severe hMPV infections of patients after lung transplantation. The new invention of the Jagiellonian University, which is the subject of the proposed offer, discloses a new drug for treatment of human metapneumovirus (hMPV) infection.

                  The human rhinovirus (HRV) belongs to the smallest known viruses (their diameter does not exceed 30 nm). During the year, particularly in winter and spring, it causes infections of the upper respiratory tract with humans, appearing as the common cold. Rhinoviruses also cause otitis media, sinusitis and inflammations of the lower respiratory tract, including bronchi

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                • Novel antiviral agent based on modified chitosanNovel antiviral agent based on modified chitosan
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                     Medical background: Coronaviruses (CoV) cause many diseases in humans
                    and animals; in particular, human pathogens include HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1 and SARS-CoV. The latter causes a condition called Severe Acute Respiratory Syndrome (SARS) – an atypical pneumonia that first appeared in China in 2002. Until now, no effective cure for SARS has been introduced into the clinic, and the treatment of that disease is merely symptomatic. Viruses of this group are also responsible for serious diseases in animals. This fact is important not only in terms of the risk of transmission into human population (the SARS case), but also – in the case of farming animals – for economic reasons.
                     Potential antiviral agent: modified natural polysaccharides (chitosan polymer).
                     Application: treatment and prevention of viral infections caused by coronaviruses in humans, including respiratory diseases manifested by impaired respiratory function.
                     Key features:
                    • Development stage: preclinical phase.
                    • IP status: several international patent application: EPO, USA, Canada, Japan, China, India (November, 2014).
                    • Confirmed ability to efficient bind of coronaviruses and inhibit their replication in vitro and/or ex vivo.
                    • Modified chitosan has antibacterial and antifungal activity, which is
                    an additional advantage of the offered polymer.
                    • The possibility to apply as a solution or spray administrated either topically to the upper respiratory tract (throat, nose, bronchial tree), orally in the case of gastrointestinal infections or intravenously for systemic therapy.

                    Licensor information
                    The Jagiellonian University, located in Kraków, Poland, is one of the oldest universities in Europe. The offered inventions have been developed by researchers of the Faculty of Chemistry and Faculty of Biochemistry, Biophysics
                    and Biotechnology of the Jagiellonian University.

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