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You selected inventions in category Biotech

  • DNA APTAMER RECOGNIZING ARGININE TAG APPLICATION IN BIOTECHNOLOGYDNA APTAMER RECOGNIZING ARGININE TAG APPLICATION...
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      The development of modern molecular biology, biotechnology and medicine is dependent on availability of high-quality protein products. They are often produced in prokaryotic or eukaryotic expression systems. Recombinant proteins are usually fused with a short oligopeptide tag to provide fast and easy purification procedure based on the affinity chromatography technique.
      The offer is a DNA aptamer that recognizes Arg-Tag.

      DNA aptamers are single-stranded short DNA oligonucleotides characterized by high specificity and affinity to target molecule. In the present invention molecular target can be any molecule: peptide, protein or DNA derivative containing Arg-Tag.
      DNA aptamer that recognizes Arg-Tag – application in:
       Purification of the target molecules containing an Arg-Tag.

      The offered Anti-Arginine Tag DNA aptamer for biotechnological applications is patent pending. Further research and development of the invention are continued at the Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University. Currently the Centre for Innovation, Technology Transfer and University Development (CITTRU) is looking for entities interested
      in commercial application of the invention.

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    • ANTI-HISTIDINE TAG DNA APTAMERS FOR BIOTECHNOLOGICAL APPLICATIONSANTI-HISTIDINE TAG DNA APTAMERS FOR...
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        Prokaryotic and eukaryotic expression systems for the production of recombinant proteins are used on a large scale in scientific research. The genetically engineered fusion tags, e.g. histidine tag (His-Tag) are used for fast and efficient purification
        of the desired recombinant proteins. The high affinity of His-Tag to the certain metal ions (cobalt, copper, nickel or zinc) enables the application
        of chromatographic media with the above mentioned ions for the purification
        or immobilization of His-Tagged proteins.

        His-Tag recombinant protein can be detected in western blotting using anti-His mono- and polyclonal antibodies. Short His-Tag can be used to investigate protein-protein interactions in techniques such as pull down assays, immunoprecpitation, co-immunoprecipitation or Far-Western blot analysis.

        DNA aptamers are single-stranded DNA oligonucleotides of approximately 4-100 nucleotides that exhibit a high affinity and specificity to their corresponding ligand. An optimal binding between target molecule and selected aptamer is possible due to the rich secondary and tertiary structures of the latter one.

        The subject of the offer are unique sequences of single-stranded DNA aptamers that recognize His-Tag and their application in biotechnology in analysis of His-Tagged molecules (peptides, proteins or DNA derivatives).


        The offered DNA aptamers can be used for analysis of molecules containing a His-Tag, and in particular to:
        • application as a agonist for anti-histidine antibodies;
        • purification and detection of the target molecules containing a His-Tag.

        In addition to the above applications, DNA aptamers can be used as molecules
        with attached tags, especially fluorescent, and in particular to label the molecular targets containing His-Tag. This type of molecules can be successfully used e.g. to study the interaction between proteins using spectroscopic techniques.


        The offered Anti-Histidine Tag DNA aptamers for biotechnological applications
        is patent pending. Further research and development of the invention are continued at the Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University. Currently the Centre for Innovation, Technology Transfer and University Development (CITTRU) is looking for entities interested
        in commercial application of the invention.

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      • No batteries needed technologyNo batteries needed technology
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          In much the same way as you are now using to start your gas grill...

          My invention* completely eliminates the need for batteries in any type of electric or fossil-fuel-powered vehicle.

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        • The subject of the offer is a group of mixed dopamine and serotonin modulatorsThe subject of the offer is a group of mixed...
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            Key facts:
            - Lead structures classified as multimodal agents (serotonin, dopamine receptors ligands)
            - Lead structures display anti-psychotic, pro-cognitive and pro-social efficacy; the latter suggesting favorable effects on negative symptoms of psychoses
            - Uncomplicated synthesis
            In vitro testing:
            - Compounds display high affinity for dopaminergic D2 and D3 receptors and serotoninergic 5-HT1A, 5-HT2A, 5-HT6, 5-HT7 receptors; they were mostly classified as D2, 5-HT2A antagonists
            - Compounds have no affinity for M1, H1 lowering the risk of side effects related to cholinergic-, histaminergic- activity
            - Lead structures are brain penetrant
            - Lead structures display acceptable CYP interaction, no toxicity (hERG)
            In vivo testing:
            - Favorable profile in tests predictive of anti-psychotic activity: PCP-induced hyperactivity, conditioned avoidance response (CAR), prepulse inhibition (PPI), social interaction
            - Pro-cognitive efficacy in the novel object recognition (NOR) test, attentional set shifting (ASST), and others suggesting an enhancement of prefrontal flexibility disturbed in schizophrenia
            - Activity was confirmed following oral administration
            - Lead structures don’t affect ECG in guinea pigs and show lack of cardiovascular effects in rats, suggesting the lack of cardio-toxicity

            Compounds may be regarded as drug candidates for the treatment of schizophrenia symptoms and cognitive impairment.

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          • hair regrowth therapy for bald head personshair regrowth therapy for bald head persons
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              I have a successful research on hair regrowth therapy for bald head person by using my hair oil. I want to suggest for selling my formula or otherwise i want to have a partners for selling my products. The major merits of my research there has side-effects at all for bald head gents only. Hereafter i also have make to prevent the hair loss for both sex. Kindly contact my address, J.Parthasarathi,S/o,A.Jawahar, 812,Mundagan St., Sivakasi - 626123. My Contact # is 9443547064.
              With thanks & regards
              J.Parthasarathi,B.Sc.,PGDMLT.

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            • Construction and application of Salmonella-based anti-cancer vaccineConstruction and application of Salmonella-based...
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                The subject of the offer is a new vaccine-based cancer therapy based on genetically modified bacterial strain of Salmonella VNP20009 that is able to target tumor tissue. Tumour targeting was enhanced by antibody fragments specific to carcinoembryonic antigen. Further genetic modofications were introduced to increase apoptosis and necrosis within the tumour microenvironment, resulting in augmented cancer-specific immunity. The vaccine exhibited potent effciency in animal studies.

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              • Composite material for prolonged release of heparinComposite material for prolonged release of...
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                  The subject of the offer is a new material in gel form that allows for prolonged release of heparin. The material is a composition of algin and hydroxypropyl cellulose, which contains immobilised heparin. Prolonged release of heparin is maintained for as long as two weeks and the rate of the process can be controlled both by the composition and temperature. The offered material have potential applications in medicine for controlled administration of heparin, as well as in tissue engineering.

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                • Visible light photoactive materials based on modified nanocrystalline titanium dioxide for disinfection and sterylizationVisible light photoactive materials based on...
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                    The subject of the offer covers materials based on modified nanocrystalline titanium dioxide that can be applied for an efficient photocatalytic microorganisms inactivation or organic pollutants degradation under visible light irradiation.

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